Seizures and Epilepsy in Autism Spectrum Disorder

Seizures are very common in individuals with autism as are abnormal electroencephalogram recordings with seizure-like activity. Additionally a diagnosis of epilepsy is found in up to 40% of children with autism and, in many cases, is refractory to treatment. The pathology that causes epilepsy also has been implemented in children with autism.

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Causes of Epilepsy in
Autism Spectrum Disorder

Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder.

Frye RE, Casanova MF, Fatemi SH, Folsom TD, Reutiman TJ, Brown GL, Edelson SM,
Slattery JC, Adams JB. Front Neurosci. 2016; 10:192

Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.

Frye RE. Epilepsy Behav. 2015; 47:147-57.

 

Treatments for seizures and epilepsy in autism spectrum disorder

A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel.

Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Slattery JC, Lau C, Hardy P, Fatemi SH, Folsom TD, Macfabe D, Adams JB. Front Public Health. 2013 Sep 13;1:31.

Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey.

Frye RE, Sreenivasula S, Adams JB. BMC Pediatr. 2011; 11:37.

 

Subclinical Electrical discharges

Prevalence, Significance and Clinical Characteristics of Seizures, Epilepsy and Subclinical Electrical Activity in Autism

Frye, R.E. NAJMS 2015; 8(3):113-122

Electroencephalogram discharges in atypical cognitive development.

Frye RE, Butler I, Strickland D, Castillo E, Papanicolaou A.
J Child Neurol. 2010; 25(5):556-66.